Endocrine Abstracts

The Indian Medical Practitioners Expressions Regarding Drug Interventions in All Aspects of Metabolic Syndrome (IMPERIAL) study-5 was planned to assess physicians’ perceptions regarding the relative importance and effectiveness of various methods used to upgrade or intensify insulin therapy in patients not achieving glycemic control.Seventy-four diabetologists/endocrinologists, with clinical experience of 20.25±5.0 years, attending a conference...

There is a relative lack of data regarding the timing and in particular the severity of hypothyroidism post Radioiodine (RI). We retrospectively examined the timing and severity of hypothyroidism following RI in 213 patients, in relation to ‘target’ and actual follow up appointments, and the introduction of a nurse-led follow-up clinic. Hypothyroidism was defined as persistent elevation of TSH – mild (TSH 6.1–10 mU/l), moderate (TSH 10.1–50 mU/l) and s...

Noradrenaline (NE) is a peripheral vasoconstrictor reducing mortality by 11% and major adverse events by two-thirds compared to dopamine [1]. NE acts as an agonist at alpha1 and beta1 receptors, with little-to-no beta2 or alpha2 activity. This vasoconstriction effect can be potent and can result in completely occluded blood vessels more frequently in the peripheries due to lower blood pressure. Septic shock accounts for nearly 1 in 10 admissions to ICU, where it is the most co...

• A 54-year old Lithuanian man presented with symptomatic hyperglycaemia and weight loss.• A diagnosis of new onset diabetes type 2 was confirmed for which he received treatment. In addition, his serum potassium remained low despite of intervention.• CXR was done and showed a bulky right sided hilar mass.• The combination of refractory hypokalaemia, hyperglycaemia, and lung cancer suspicio...

Introduction: Long-term survivors of childhood-onset brain tumours have increased risk of premature vascular disease by mechanisms that remain unclear. We hypothesised that a thrombotic fibrin network profile is one mechanism for the increased vascular risk in this population.Methods: We undertook a cross-sectional study in 33 patients with previous history of brain tumours and 33 age and sex-matched healthy controls. We performed clot structure analysis...

Introduction: Childhood-onset cancer survivors demonstrate increased mortality rates due to cardiovascular and cerebrovascular events. Studies suggest that leukaemia and brain tumour survivors have a relative risk of 6.4 and 29.0 respectively for stroke. Adverse lipid profile, body composition, insulin resistance and hypertension have been implicated to the increased cardiovascular risk in these patients, however little is known about procoagulant factors and markers of vascul...

Antiphospholipid antibody (APLA) syndrome is a rare autoimmune systemic disorder which can occur as primary condition or secondary to connective tissue diseases, most frequently systemic lupus erythematosis. We are presenting a rare case of a lady who developed adrenal insufficiency secondary to adrenal vein thrombosis, as a late sequel to APLA Syndrome.A 50-year-old lady admitted to the medical ICU with one day’s history of severe abdominal pain an...

This multicentric, observational, non interventional study of patients with type 1 diabetes observed their knowledge, attitudes and practices regarding complementary and alternative medicine (CAM), including nutraceuticals. One hundred and thirty-five subjects with type 1 diabetes, aged <20 years, and their parents were surveyed using a structured pre-tested questionnaire.The cohort included 65.92% boys, 37.04% rural dwellers and 31.85% patients with...

Introduction: Childhood-onset brain tumour (CO-BT) survivors demonstrate elevated standardized mortality rates for cardiac disease. Adverse lipid profile and body composition contribute to the increased cardiovascular risk. Little is known about the metabolic changes in long-term survivors of adult-onset brain tumours (AO-BT).Methods: We performed a cross-sectional study to compare cardiovascular risk parameters in CO-BT with AO-BT survivors and healthy ...

Introduction: There is strong evidence that adult survivors of childhood cancer have excess premature vascular morbidity and mortality, the pathophysiological mechanism of which remains unresolved.Methods: We undertook a cross sectional study to assess cardiovascular risk in long-term survivors of brain tumours following cranial irradiation compared with healthy matched controls. The following cardiovascular markers were measured: full lipid profile, fas...